Article
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
Nature communications - 9 Nov 2020
Sequeira Inês, Rashid Mamunur, Tomás Inês M, Williams Marc J, Graham Trevor A, Adams David J, Vigilante Alessandra, Watt Fiona M
Abstract excerpt
To establish whether 4-nitroquinoline N-oxide-induced carcinogenesis mirrors the heterogeneity of human oral squamous cell carcinoma (OSCC), we have performed genomic analysis of mouse tongue lesions. The mutational signatures of human and mouse OSCC overlap extensively. Mutational burden is higher in moderate dysplasias and invasive SCCs than in hyperplasias and mild dysplasias, although mutations in p53, Notch1...
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