Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm.

Neuroscience - 1 Aug 2020

Muneoka Katsumasa, Oda Yasunori, Iwata Masaaki, Iyo Masaomi, Hashimoto Kenji, Shirayama Yukihiko

Abstract excerpt

Monoamine neuronal system abnormality is hypothesized to be the neurochemical pathology in depression, as it is supported by the efficacy of conventional antidepressants. The learned helplessness paradigm generates depression-like (LH) and non-depression-like (non-LH) behavioral models. Examination of the neurochemical states accompanying such distinct behavioral phenotypes can facilitate investigations of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Hydroxyindoleacetic Acid
Share to Norepinephrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Serotonin

Source

Identifiers

PMID: 32222554
DOI: 10.1016/j.neuroscience.2020.03.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm.PMID 32222554Read ↗

Understanding the role of serotonin in psychiatric diseasesSemantic proximity Read ↗

Serotonergic plasticity in the dorsal raphe nucleus characterizes susceptibility and resilience to anhedoniaSemantic proximity Read ↗

Stress vulnerability promotes an alcohol prone phenotype in a preclinical model of sustained depressionSemantic proximity Read ↗

The neurobiology of depression.Semantic proximity Read ↗

Hyperactivity of the Amygdala Mediates Depressive-Like Phenotypes and Decreased Serotonin ReleaseSemantic proximity Read ↗

2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.Semantic proximity Read ↗

Individual differences in novelty-seeking predict differential responses to chronic antidepressant treatment through sex- and phenotype-dependent neurochemical signatures.Semantic proximity Read ↗

Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandemSemantic proximity Read ↗

Hyperactivity of the Amygdala Mediates Depressive-Like Phenotypes and Decreased Serotonin ReleaseSemantic proximity Read ↗

A chronic treatment with fluoxetine decreases 5-HT(1A) receptors labeling in mice selected as a genetic model of helplessness.Semantic proximity Read ↗

Structural and functional models of depression: from sub-types to substrates.Semantic proximity Read ↗

Depression-like phenotype following chronic CB1 receptor antagonism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.