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Article

PepO is a target of the two-component systems VicRK and CovR required for systemic virulence of Streptococcus mutans

19 May 2020

Abstract excerpt

Streptococcus mutans , a cariogenic species, is often associated with cardiovascular infections. Systemic virulence of specific S. mutans serotypes has been associated with the expression of the collagen- and laminin-binding protein Cnm, which is transcriptionally regulated by VicRK and CovR. In this study, we characterized a VicRK- and CovR-regulated gene, pepO, coding for a conserved endopeptidase....

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Identifiers

PMID: 32427040
DOI: 10.1080/21505594.2020.1767377

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