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Cnm is a major virulence factor of invasive<i>Streptococcus mutans</i>and part of a conserved three-gene locus

8 Oct 2013

Abstract excerpt

Cnm, a collagen- and laminin-binding protein present in a subset of Streptococcus mutans strains, mediates binding to extracellular matrices (ECM), intracellular invasion and virulence in the Galleria mellonella model. Antibodies raised against Cnm were used to confirm expression and the cell surface localization of Cnm in the highly invasive OMZ175 strain. Sequence analysis identified two additional genes (cnaB...

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PMID: 24103776
DOI: 10.1111/mom.12041

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