Article
Signal pathway analysis of selected obesity-associated melanocortin-4 receptor class V mutants.
Biochimica et biophysica acta. Molecular basis of disease - 1 Aug 2020
Sharma Sunita, Thibodeau Stephanie, Lytton Jonathan
Abstract excerpt
Mutations in the melanocortin-4 receptor (MC4R) in humans are the single most common cause of rare monogenic 1severe obesity, and polymorphisms in this gene are also associated with obesity in the general population. The MC4R is a G-protein coupled receptor, and in vitro analysis suggests that MC4R can signal through several different G-protein subtypes. In vivo studies show complex outcomes, with different...
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