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Article

Fam20C regulates protein secretion by Cab45 phosphorylation.

The Journal of cell biology - 1 Jun 2020

Hecht Tobias Karl-Heinz, Blank Birgit, Steger Martin, Lopez Victor, Beck Gisela, Ramazanov Bulat, Mann Matthias, Tagliabracci Vincent, von Blume Julia

Abstract excerpt

The TGN is a key compartment for the sorting and secretion of newly synthesized proteins. At the TGN, soluble proteins are sorted based on the instructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves the cargo-sorting protein Cab45. Here, we show that Cab45 is phosphorylated by the Golgi-specific protein kinase Fam20C. Mimicking of phosphorylation translocates Cab45 into...

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Identifiers

PMID: 32422653
DOI: 10.1083/jcb.201910089
PMCID: PMC7265331

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