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Article

Cellular levels of the syntaxin Tlg2p are regulated by a single mode of binding to Vps45p.

Biochemical and biophysical research communications - 23 Nov 2007

Carpp Lindsay N, Shanks Scott G, Struthers Marion S, Bryant Nia J

Abstract excerpt

Sec1p/Munc18 (SM) proteins play a key role in the regulation of soluble N-ethylmaleimide-sensitive fusion (NSF)-attachment protein receptor (SNARE)-mediated intracellular membrane trafficking events in all eukaryotic cells. Understanding the molecular mechanisms by which SM proteins function has not been straight forward as SM proteins bind to their cognate SNARE proteins by at least two distinct mechanisms,...

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Source

Identifiers

PMID: 17904527
DOI: 10.1016/j.bbrc.2007.09.067

Genes

NSF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Cellular levels of the syntaxin Tlg2p are regulated by a single mode of binding to Vps45p.PMID 17904527Read ↗

The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p.Semantic proximity Read ↗

The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes.Semantic proximity Read ↗

Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation.Semantic proximity Read ↗

The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structure-based functional analysis reveals a role for the SM protein Sly1p in retrograde transport to the endoplasmic reticulum.Semantic proximity Read ↗

How Tlg2p/syntaxin 16 'snares’ Vps45Semantic proximity Read ↗

Mso1p regulates membrane fusion through interactions with the putative N-peptide-binding area in Sec1p domain 1.Semantic proximity Read ↗

Two syntaxin homologues in the TGN/endosomal system of yeast.Semantic proximity Read ↗

Dfm1 promotes Ste24-dependent translocon quality controlSemantic proximity Read ↗

Syntaxin binding mechanism and disease-causing mutations in Munc18-2Semantic proximity Read ↗

Membrane targeting of the yeast exocyst complex.Semantic proximity Read ↗

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.Semantic proximity Read ↗

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