Article
Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates.
Neurobiology of disease - 1 Jul 2020
Gosset Philippe, Maxan Alexander, Alpaugh Melanie, Breger Ludivine, Dehay Benjamin, Tao Zhu, Ling Zhang, Qin Chuan, Cisbani Giulia, Fortin Nadia, Vonsattel Jean-Paul G, Lacroix Steve, Oueslati Abid, Bezard Erwan, Cicchetti Francesca
Abstract excerpt
In recent years, substantial evidence has emerged to suggest that spreading of pathological proteins contributes to disease pathology in numerous neurodegenerative disorders. Work from our laboratory and others have shown that, despite its strictly genetic nature, Huntington's disease (HD) may be another condition in which this mechanism contributes to pathology. In this study, we set out to determine if the...
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