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Article

Huntington disease models and human neuropathology: similarities and differences.

Acta neuropathologica - 1 Jan 2008

Vonsattel Jean Paul G

Abstract excerpt

Huntington disease (HD) occurs only in humans. Thus, its natural pathogenesis takes place exclusively within the human brains expressing the causative, mutated protein huntingtin (mhtt). The techniques applicable to postmortem human HD brains are inadequate for investigating the cellular pathogenesis. The creation of genetically engineered animals represents a critical moment in neuroscience. Monitoring the...

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Identifiers

PMID: 17978822
DOI: 10.1007/s00401-007-0306-6
PMCID: PMC2847401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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