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Long‐term repopulation of aged bone marrow stem cells using young Sca‐1 cells promotes aged heart rejuvenation

5 Aug 2019

Abstract excerpt

Abstract Reduced quantity and quality of stem cells in aged individuals hinders cardiac repair and regeneration after injury. We used young bone marrow (BM) stem cell antigen 1 (Sca‐1) cells to reconstitute aged BM and rejuvenate the aged heart, and examined the underlying molecular mechanisms. BM Sca‐1 + or Sca‐1 − cells from young (2–3 months) or aged (18–19 months) GFP transgenic mice were transplanted into...

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PMID: 31385396
DOI: 10.1111/acel.13026

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