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Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.

Psychiatry research. Neuroimaging - 30 Jul 2020

Ardekani Babak A, Izadi Neema O, Hadid Somar A, Meftah Amir M, Bachman Alvin H

Abstract excerpt

Early detection of Alzheimer's disease (AD) is important for timely interventions and developing new treatments. Hippocampus atrophy is an early biomarker of AD. The hippocampal parenchymal fraction (HPF) is a promising measure of hippocampal structural integrity computed from structural MRI. It is important to characterize the dependence of HPF on covariates such as age and sex in the normal population to...

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PMID: 32416384
DOI: 10.1016/j.pscychresns.2020.111107

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