Article
Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2).
Hepatology (Baltimore, Md.) - 1 Feb 2021
Al-Naamani Nadine, Krowka Michael J, Forde Kimberly A, Krok Karen L, Feng Rui, Heresi Gustavo A, Dweik Raed A, Bartolome Sonja, Bull Todd M, Roberts Kari E, Austin Eric D, Hemnes Anna R, Patel Mamta J, Oh Jae K, Lin Grace, Doyle Margaret F, Denver Nina, Andrew Ruth, MacLean Margaret R, Fallon Michael B, Kawut Steven M
Abstract excerpt
BACKGROUND AND AIMS: Portopulmonary hypertension (POPH) was previously associated with a single-nucleotide polymorphism (SNP) rs7175922 in aromatase (cytochrome P450 family 19 subfamily A member 1 [CYP19A1]). We sought to determine whether genetic variants and metabolites in the estrogen signaling pathway are associated with POPH. APPROACH AND RESULTS: We performed a multicenter case-control study. POPH patients...
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