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Article

Methylation analysis of the SLC19A1 promoter region in Chinese children with acute lymphoblastic leukaemia.

Journal of clinical pharmacy and therapeutics - 1 Aug 2020

Wang Shu-Mei, Li Miao, Wu Wan-Shui, Sun Lu-Lu, Yan Dan

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Reduced folate carrier 1 (RFC1), which is encoded by the human solute carrier family 19 member 1 (SLC19A1) gene, plays an essential role in the cellular uptake of methotrexate (MTX). RFC1 expression is regulated by genetic variations and epigenetic modifications. The aim of the present study was to investigate the methylation status of the SLC19A1 promoter in peripheral blood and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32403197
DOI: 10.1111/jcpt.13171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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