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Article

The association of reduced folate carrier 80G>A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number.

Blood - 10 Jun 2010

Gregers Jannie, Christensen Ib Jarle, Dalhoff Kim, Lausen Birgitte, Schroeder Henrik, Rosthoej Steen, Carlsen Niels, Schmiegelow Kjeld, Peterson Curt

Abstract excerpt

The reduced folate carrier (RFC) is involved in the transport of methotrexate (MTX) across the cell membrane. The RFC gene (SLC19A1) is located on chromosome 21, and we hypothesized that the RFC80 G>A polymorphism would affect outcome and toxicity in childhood leukemia and that this could interac...

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Identifiers

PMID: 20335220
DOI: 10.1182/blood-2010-01-256958
PMCID: PMC2890175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20335220-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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