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Article

Association between MTHFR microRNA binding site polymorphisms and methotrexate concentrations in Chinese pediatric patients with acute lymphoblastic leukemia.

The journal of gene medicine - 1 Nov 2017

Wang Shu-Mei, Zeng Wei-Xin, Wu Wan-Shui, Sun Lu-Lu, Yan Dan

Abstract excerpt

BACKGROUND: The pharmacokinetics and therapeutic response to methotrexate (MTX) display large variability in the treatment of acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the association of two microRNA (miRNA) binding site polymorphisms (rs3737966 G > A and rs35134728 DEL/TTC) in the 3'-untranslated region of MTHFR with serum MTX concentrations, in a Chinese pediatric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to 3' Untranslated Regions
Share to Antimetabolites, Antineoplastic
Share to Binding Sites
Share to Linkage Disequilibrium
Share to Methotrexate
Share to Methylenetetrahydrofolate Reductase (NADPH2)
Share to MicroRNAs
Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 28990296
DOI: 10.1002/jgm.2990

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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