Article
Screening for deafness-associated mitochondrial 12S rRNA mutations by using a multiplex allele-specific PCR method.
Bioscience reports - 29 May 2020
Ding Yu, Lang Jianyong, Zhang Junkun, Xu Jianfeng, Lin Xiaojiang, Lou Xiangyu, Zheng Hui, Huai Lei
Abstract excerpt
Mitochondrial 12S rRNA A1555G and C1494T mutations are the major contributors to hearing loss. As patients with these mutations are sensitive to aminoglycosides, mutational screening for 12S rRNA is therefore recommended before the use of aminoglycosides. Most recently, we developed a novel multiplex allele-specific PCR (MAS-PCR) that can be used for detecting A1555G and C1494T mutations. In the present study, we...
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