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Article

MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia

12 May 2020

Abstract excerpt

Despite growing awareness of the biologic features underlying MLL-rearranged leukemia, targeted therapies for this leukemia have remained elusive and clinical outcomes remain dismal. MBNL1, a protein involved in alternative splicing, is consistently overexpressed in MLL-rearranged leukemias. We found that MBNL1 loss significantly impairs propagation of murine and human MLL-rearranged leukemia in vitro and in...

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PMID: 32398749
DOI: 10.1038/s41467-020-15733-8

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