Article

Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7B

2023-04-21

Abstract excerpt

We suggest a model of apico-basolateral sorting in polarized epithelia using homologous Cu-ATPases as membrane cargoes. In polarized epithelia, upon copper treatment, homologous copper-ATPases ATP7A and ATP7B traffic from trans-Golgi network (TGN) to basolateral and apical membranes respectively. We characterized sorting pathways of Cu-ATPases between TGN and plasma-membrane and identified the machinery involved....

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Literature Corpus work: d4c1f717-ea59-5aa3-8b77-49fd45ea8032
DOI: 10.1101/2023.04.19.537613

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