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Rethinking mitochondrial heteroplasmy: selection, conflict and adaptation.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 2 Apr 2026

Kannangara Jade R, Ma Hansong, Dowling Damian K

Abstract excerpt

Mitochondrial DNA (mtDNA) variation is increasingly recognized for its role in shaping evolutionary changes at the species and population levels. Yet, its evolutionary relevance within individuals remains less explored. Eukaryotic cells typically carry multiple copies of mtDNA. When these copies differ in sequence, heteroplasmy arises-a form of intra-organismal genetic diversity with potentially profound...

Topics

Selection, Genetic
Animals
DNA, Mitochondrial
Heteroplasmy
Biological Evolution
Adaptation, Physiological
Adaptation, Biological
Genetic Variation
Evolution, Molecular

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PMID: 41923601
DOI: 10.1098/rstb.2025.0079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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