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Article

Nuclear compensatory evolution driven by mito-nuclear incompatibilities.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2024

Princepe Debora, de Aguiar Marcus A M

Abstract excerpt

Mitochondrial function relies on the coordinated expression of mitochondrial and nuclear genes, exhibiting remarkable resilience despite high mitochondrial mutation rates. The nuclear compensation mechanism suggests deleterious mitochondrial alleles drive compensatory nuclear mutations to preserve mito-nuclear compatibility. However, prevalence and factors conditioning this phenomenon remain debated due to its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39392668
DOI: 10.1073/pnas.2411672121
PMCID: PMC11494290

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