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Article

Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution.

BMC evolutionary biology - 26 Feb 2008

Howe Dana K, Denver Dee R

Abstract excerpt

BACKGROUND: The theory of Muller' Ratchet predicts that small asexual populations are doomed to accumulate ever-increasing deleterious mutation loads as a consequence of the magnified power of genetic drift and mutation that accompanies small population size. Evidence for Muller's Ratchet and knowledge on its underlying molecular mechanisms, however, are lacking for natural populations. RESULTS: We characterized...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18302772
DOI: 10.1186/1471-2148-8-62
PMCID: PMC2279117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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