Article
Impact of Low Birth Weight and Prematurity on Neonatal Raltegravir Pharmacokinetics: Impaact P1097.
Journal of acquired immune deficiency syndromes (1999) - 15 Dec 2020
Clarke Diana F, Lommerse Jos, Acosta Edward P, Cababasay Mae P, Wang Jiajia, Spector Stephen A, Chain Anne, Smith Elizabeth, Teppler Hedy, Hazra Rohan, Calabrese Kat, Graham Bobbie, Popson Stephanie, Bryson Yvonne, Mirochnick Mark
Abstract excerpt
BACKGROUND: HIV treatment of neonates requires identifying appropriate antiretroviral dosing regimens. Our aims were to characterize raltegravir elimination kinetics in low birth weight (LBW) neonates after maternal dosing and to develop a pharmacokinetic model to predict raltegravir plasma concentrations for term and preterm neonates. METHODS: Mothers living with HIV who received raltegravir during pregnancy and...
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