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Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

28 Jul 2021

Abstract excerpt

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles gambiae effectively suppressed the reproductive capability of mosquito populations reared in small laboratory cages. To bridge the gap between laboratory and the field, this gene-drive technology must be challenged with vector ecology.Here we report the suppressive activity of the gene-drive in age-structured An. gambiae...

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PMID: 34321476
DOI: 10.1038/s41467-021-24790-6

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