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Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells

22 Apr 2020

Abstract excerpt

The term cancer stem cell (CSC) starts 25 years ago with the evidence that CSC is a subpopulation of tumor cells that have renewal ability and can differentiate into several distinct linages. Therefore, CSCs play crucial role in the initiation and the maintenance of cancer. Moreover, it has been proposed throughout several studies that CSCs are behind the failure of the conventional chemo/radiotherapy as well as...

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PMID: 32391048
DOI: 10.3389/fgene.2020.00312

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