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Cancer stem cells and tumorigenesis

1 Aug 2018

Abstract excerpt

Cancer is one of the most serious diseases all over the world, and the cancer stem cell (CSC) model accounts for tumor initiation, metastasis, drug resistance, and relapse. The CSCs within tumor bulk have the capacity to self-renew, differentiate, and give rise to a new tumor. The self-renewal of CSCs is precisely regulated by various modulators, including Wnt/β-catenin signaling, Notch signaling, Hedgehog...

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PMID: 30310855
DOI: 10.1007/s41048-018-0062-2

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