Article
13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking.
Blood - 20 Aug 2020
Yang Minjun, Safavi Setareh, Woodward Eleanor L, Duployez Nicolas, Olsson-Arvidsson Linda, Ungerbäck Jonas, Sigvardsson Mikael, Zaliova Marketa, Zuna Jan, Fioretos Thoas, Johansson Bertil, Nord Karolin H, Paulsson Kajsa
Abstract excerpt
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among the most common driver events in acute leukemia, leading to increased cell proliferation and survival through activation of the phosphatidylinositol 3-kinase/AKT-, RAS/MAPK-, and STAT5-signaling pathways. In this study, we examine the pathogenetic impact of somatic hemizygous 13q12.2 microdeletions in B-cell precursor (BCP) acute...
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