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Detection of Somatic Mutations with ddPCR from Liquid Biopsy of Colorectal Cancer Patients.

Genes - 19 Feb 2021

Zmrzljak Uršula Prosenc, Košir Rok, Krivokapić Zoran, Radojković Dragica, Nikolić Aleksandra

Abstract excerpt

Liquid biopsy and cell-free DNA (cfDNA) show great promise in cancer diagnostics. In this study, we designed a custom droplet digital PCR (ddPCR) assay for the quantification and quality control of cfDNA isolated from serum. The assay was validated on a group of locally advanced colorectal cancer (CRC) patients and two control groups-patients with hemorrhoids and healthy individuals. The assay shows a high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33669856
DOI: 10.3390/genes12020289
PMCID: PMC7923234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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