Article
Evolutionary selection of pestivirus variants with altered or no microRNA dependency.
Nucleic acids research - 4 Jun 2020
Kokkonos Konstantinos G, Fossat Nicolas, Nielsen Louise, Holm Christina, Hepkema Wytske M, Bukh Jens, Scheel Troels K H
Abstract excerpt
Host microRNA (miRNA) dependency is a hallmark of the human pathogen hepatitis C virus (HCV) and was also described for the related pestiviruses, which are important livestock pathogens. The liver-specific miR-122 binds within the HCV 5' untranslated region (UTR), whereas the broadly expressed let-7 and miR-17 families bind two sites (S1 and S2, respectively) in the pestiviral 3' UTR. Here, we dissected the...
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