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HDAC1-3 inhibition reduces CCR2 expression and immunosuppressive function of myeloid-derived suppressor cells

2023-06-05

Abstract excerpt

Myeloid-derived suppressor cells (MDSCs) play a critical role in cancer progression and resistance, making them significant targets for cancer immunotherapy. Although epigenetic regulation by histone deacetylases (HDACs) regulates cell fate and function, the specific roles of HDACs in modulating MDSCs remain poorly understood. We aimed to examine the effects and underlying mechanisms of HDAC on MDSCs using various...

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Literature Corpus work
6b4cb764-1414-515a-a45f-3df23fa17800
DOI
10.1101/2023.06.01.543360
Open publication

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HDAC1-3 inhibition reduces CCR2 expression and immunosuppressive function of myeloid-derived suppressor cellsDOI 10.1101/2023.06.01.543360
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