Article
Frequent KIT mutations in skin lesions of patients with BRAF wild-type Langerhans cell histiocytosis.
Virchows Archiv : an international journal of pathology - 1 Nov 2020
Tóth Béla, Kiss Norbert, Hársing Judit, Kárpáti Sarolta, Csomor Judit, Bödör Csaba, Tímár József, Rásó Erzsébet
Abstract excerpt
Langerhans cell histiocytosis (LCH) is characterized by mutations of the RAS-RAF-MAPK signaling pathway. We analyzed MAP2K1, NRAS and KIT mutation incidence in skin lesions of BRAF wild-type (wt) LCH patients. We evaluated the occurrence of MAP2K1, NRAS and KIT mutations in seven LCH and one indeterminate cell histiocytosis (ICH) patients. MAP2K1 mutation frequency was found to be 3/7 (42.9%) in LCH and also...
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