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Article

MAPK/ERK signal pathway alterations in patients with Langerhans Cell Histiocytosis.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 1 Jan 2000

Novosad Olga, Skrypets Tanya, Pastushenko Yan, Titorenko Iryna, Martynchyk Arina, Skachkova Oksana, Inomistova Mariia, Gorbach Alex, Khranovska Nataliia, Kryachok Irina

Abstract excerpt

BACKGROUND: Clinical outcomes of Langerhans cell histiocytosis (LCH) are highly variable. It has been suggested that mitogen-activated protein kinase (MAPK) /extracellular signal-regulated kinases (ERK) signaling pathway might be activated in LCH patients. MATERIALS AND METHODS: We investigated KRAS, BRAF and NRAS mutations in patients with LCH by qPCR. RESULTS: Eight adult patients with LCH were treated at the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29708356
DOI: 10.14735/amko2018130

Genes

NRAS
BRAF
KRAS
TTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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