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Article

CCR5 blockade inflames antitumor immunity in BAP1-mutant clear cell renal cell carcinoma.

Journal for immunotherapy of cancer - 1 Apr 2020

Zhou Quan, Qi Yangyang, Wang Zewei, Zeng Han, Zhang Hongyu, Liu Zhaopei, Huang Qiuren, Xiong Ying, Wang Jiajun, Chang Yuan, Bai Qi, Xia Yu, Wang Yiwei, Liu Li, Xu Le, Dai Bo, Guo Jianming, Zhu Yu, Zhang Weijuan, Xu Jiejie

Abstract excerpt

BACKGROUND: Patients with BRCA1-associated protein 1 (BAP1)-mutant clear cell renal cell carcinoma (ccRCC) have worse prognosis. C-C chemokine receptor 5 (CCR5) plays an important role in ccRCC development and its expression is elevated in BAP1-mutant tumors. METHODS: 533 patients with ccRCC from The Cancer Genome Atlas cohort and 797 patients with ccRCC from the Shanghai cohort were enrolled. In vitro and in...

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Identifiers

PMID: 32371459
DOI: 10.1136/jitc-2019-000228
PMCID: PMC7228663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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