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Article

Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma

22 Aug 2018

Abstract excerpt

Although a subset of clear cell renal cell carcinoma (ccRCC) patients respond to immune checkpoint blockade (ICB), predictors of response remain uncertain. We investigated whether abnormal expression of endogenous retroviruses (ERVs) in tumors is associated with local immune checkpoint activation (ICA) and response to ICB. Twenty potentially immunogenic ERVs (πERVs) were identified in ccRCC in The Cancer Genome...

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PMID: 30135306
DOI: 10.1172/jci.insight.121522

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