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Article

The expanding role of BAP1 in clear cell renal cell carcinoma.

Human pathology - 1 Mar 2023

Kapur Payal, Rajaram Satwik, Brugarolas James

Abstract excerpt

Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.

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Identifiers

PMID: 35932824
DOI: 10.1016/j.humpath.2022.07.022
PMCID: PMC9898467

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