Article
Comparison of personal and shared frameshift neoantigen vaccines in a mouse mammary cancer model.
BMC immunology - 5 May 2020
Peterson Milene, Murphy Sierra Nicole, Lainson John, Zhang Jian, Shen Luhui, Diehnelt Chris W, Johnston Stephen Albert
Abstract excerpt
BACKGROUND: It is widely hoped that personal cancer vaccines will extend the number of patients benefiting from checkpoint and other immunotherapies. However, it is clear creating such vaccines will be challenging. It requires obtaining and sequencing tumor DNA/RNA, predicting potentially immunogenic neoepitopes and manufacturing a one-use vaccine. This process takes time and considerable cost. Importantly, most...
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