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Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts

4 May 2020

Abstract excerpt

Cell fusion occurs when several cells combine to form a multinuclear aggregate (syncytium). In human placenta, a syncytialized trophoblast (syncytiotrophoblast) layer forms the primary interface between maternal and fetal tissue, facilitates nutrient and gas exchange, and produces hormones vital for pregnancy. Syncytiotrophoblast development occurs by differentiation of underlying progenitor cells called...

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Share to Epigenetics and DNA Methylation
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PMID: 32366868
DOI: 10.1038/s41419-020-2500-6

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