Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluating the role of DNA methyltransferases in trophoblast fusion and preeclampsia development: Insights from methylation‐regulated genes

15 Jun 2024

Abstract excerpt

The etiology of preeclampsia (PE), a complex and multifactorial condition, remains incompletely understood. DNA methylation, which is primarily regulated by three DNA methyltransferases (DNMTs), DNMT1, DNMT3A, and DNMT3B, plays a vital role in early embryonic development and trophectoderm differentiation. Yet, how DNMTs modulate trophoblast fusion and PE development remains unclear. In this study, we found that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Epigenetics and DNA Methylation
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38877842
DOI: 10.1096/fj.202302705r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluating the role of DNA methyltransferases in trophoblast fusion and preeclampsia development: Insights from methylation‐regulated genesPMID 38877842Read ↗

Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placentaSemantic proximity Read ↗

The role of DNA methylation in human trophoblast differentiationSemantic proximity Read ↗

Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblastsSemantic proximity Read ↗

Epigenetic Changes Regulating Epithelial–Mesenchymal Plasticity in Human Trophoblast DifferentiationSemantic proximity Read ↗

The placenta: transcriptional, epigenetic, and physiological integration during developmentSemantic proximity Read ↗

Dysregulated DNA Methyltransferase 3A Upregulates IGFBP5 to Suppress Trophoblast Cell Migration and Invasion in PreeclampsiaSemantic proximity Read ↗

Developmentally Delayed Epigenetic Reprogramming Underlying the Pathogenesis of PreeclampsiaSemantic proximity Read ↗

DNA methylation-associated repression of MEST/PEG1 expression contributes to the invasion of extravillous trophoblast cellsSemantic proximity Read ↗

Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiationSemantic proximity Read ↗

DNA methylation maintenance by DNMT1 is essential for human trophoblast stem cell homeostasis and differentiationSemantic proximity Read ↗

Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasionSemantic proximity Read ↗

Epigenetic modifications at DMRs of placental genes are subjected to variations in normal gestation, pathological conditions and folate supplementation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.