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Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

17 Apr 2020

Abstract excerpt

Rotaviruses are a large and evolving population of segmented double-stranded RNA viruses that cause severe gastroenteritis in the young of many mammalian and avian host species, including humans. With the recent advent of rotavirus reverse genetics systems, it has become possible to use directed mutagenesis to explore rotavirus biology, modify and optimize existing rotavirus vaccines, and develop rotavirus...

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PMID: 32364550
DOI: 10.3791/61039

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