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FAST Proteins: Development and Use of Reverse Genetics Systems for Reoviridae Viruses

29 Sept 2021

Abstract excerpt

Reverse genetics systems for viruses, the technology used to generate gene-engineered recombinant viruses from artificial genes, enable the study of the roles of the individual nucleotides and amino acids of viral genes and proteins in infectivity, replication, and pathogenicity. The successful development of a reverse genetics system for poliovirus in 1981 accelerated the establishment of protocols for other RNA...

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PMID: 34586868
DOI: 10.1146/annurev-virology-091919-070225

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