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Article

HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells.

Molecular oncology - 1 Feb 2009

Niu Dandan, Zhang Jianhua, Ren Yudan, Feng Huixing, Chen Wei Ning

Abstract excerpt

Epigenetics has been implicated in human cancer development. Epigenetic factors include HBx protein, which is able to induce hypermethylation and suppresses tumor suppressor genes. One of such tumor suppressor genes, GSTP1, shows reduced expression in many human cancers. Hypermethylation of GSTP1 is the most studied mechanism of its silence. In the present study, we reported that GSTP1 expression was completely...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19383368
DOI: 10.1016/j.molonc.2008.10.002
PMCID: PMC5527876

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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