Article
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.
Archives of biochemistry and biophysics - 15 Jul 2020
García-Palmero Irene, Shah Neelam, Ali Naveid A, Daly Roger J, Wilce Jacqueline A, Villalobo Antonio
Abstract excerpt
Growth factor receptor bound protein 7 (Grb7) is a mammalian adaptor protein participating in signaling pathways implicated in cell migration, metastatic invasion, cell proliferation and tumor-associated angiogenesis. We expressed tagged versions of wild type Grb7 and the mutant Grb7Δ, lacking its calmodulin-binding domain (CaM-BD), in human embryonic kidney (HEK) 293 cells and rat glioma C6 cells to identify...
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