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Article

Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma.

Theranostics - 1 Jan 2020

Liang Xiaoting, Wang Xin, He Yaohui, Wu Yuanzhong, Zhong Li, Liu Wen, Liao Dan, Kang Tiebang

Abstract excerpt

Background: Rab22a-NeoF1 fusion gene containing the 1-38aa of Rab22a (Rab22a1-38) plays a decisive role in driving tumor metastasis by activating RhoA via binding to SmgGDS607. However, its intercellular regulation remains unknown. Methods: The Lys7 (K7) acetylation of Rab22a-NeoF1 was initially identified by mass spectrum. Co-transfection, immunoprecipitation and Western blotting were used to characterize the...

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Identifiers

PMID: 32685017
DOI: 10.7150/thno.46082
PMCID: PMC7359080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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