Article
Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.
The Journal of biological chemistry - 27 Jul 2007
Abbott Rachel J M, Spendlove Ian, Roversi Pietro, Fitzgibbon Hannah, Knott Vroni, Teriete Peter, McDonnell James M, Handford Penny A, Lea Susan M
Abstract excerpt
CD97, the archetypal member of the EGF-TM7 protein family, is constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells following activation. The key isoform of CD97 expressed on leukocytes binds the complement regulatory protein CD55 (also termed decay-accelerating factor). CD97 has been shown recently to mediate co-stimulation of T cells via CD55. Here, we demonstrate that...
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