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Article

Construction and application of 3-fucosyllactose whole-cell biosensor for high-throughput screening of overproducers.

Bioresource technology - 1 Jun 2024

Li Qinggang, Liu Chuan, He Jinhuai, Liu Tiantian, Zhang Wencong, Xie Zhenzhen, Zong Jianfei, Li Yu, Sun Xue, Lu Fuping

Abstract excerpt

Biosensor-based high-throughput screening is efficient for improving industrial microorganisms. There is a severe shortage of human milk oligosaccharides (HMOs) biosensors. This study established a 3-fucosyllactose (3-FL, a kind of HMOs) whole-cell biosensor by coupling cell growth with production. To construct and optimize the biosensor, an Escherichia coli 3-FL producer was engineered by deleting the manA, yihS...

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Identifiers

PMID: 38705212
DOI: 10.1016/j.biortech.2024.130798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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