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Article

1,2-alpha-l-Fucosynthase: a glycosynthase derived from an inverting alpha-glycosidase with an unusual reaction mechanism.

FEBS letters - 12 Nov 2008

Wada Jun, Honda Yuji, Nagae Masamichi, Kato Ryuichi, Wakatsuki Soichi, Katayama Takane, Taniguchi Hajime, Kumagai Hidehiko, Kitaoka Motomitsu, Yamamoto Kenji

Abstract excerpt

Fucosyloligosaccharides have great therapeutic potential. Here we present a new route for synthesizing a Fucalpha1,2Gal linkage by introducing glycosynthase technology into 1,2-alpha-l-fucosidase. The enzyme adopts a unique reaction mechanism, in which asparagine-423 activated by aspartic acid-76...

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PMID: 18845150
DOI: 10.1016/j.febslet.2008.09.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18845150-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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