Article
Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019.
The Journal of infectious diseases - 16 Jun 2020
Zhang Yonghong, Qin Ling, Zhao Yan, Zhang Ping, Xu Bin, Li Kang, Liang Lianchun, Zhang Chi, Dai Yanchao, Feng Yingmei, Sun Jianping, Hu Zhongjie, Xiang Haiping, Knight Julian C, Dong Tao, Jin Ronghua
Abstract excerpt
A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Betacoronavirus
- COVID-19
- Cohort Studies
- Coronavirus Infections