Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality.

doi:10.1016/j.cyto.2022.155957

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Article

Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality.

Cytokine - 1 Sept 2022

Ahmadi Iraj, Afifipour Alireza, Sakhaee Fatemeh, Zamani Mohammad Saber, Mirzaei Gheinari Fahimeh, Anvari Enayat, Fateh Abolfazl

Abstract excerpt

BACKGROUND AND AIMS: Interferon-induced transmembrane protein 3 (IFITM3) plays a critical role in the adaptive and innate immune response by preventing membrane hemifusion between the host and viral cell cytoplasm. This study aimed to evaluate whether IFITM3 rs12252 polymorphism is related to an increased mortality rate of coronavirus disease 2019 (COVID-19). METHODS: The IFITM3 rs12252 polymorphism was genotyped...

Topics

COVID-19
Genetic Predisposition to Disease
Humans
Influenza, Human
Interferons
Membrane Proteins
Polymorphism, Single Nucleotide
RNA-Binding Proteins
SARS-CoV-2

Source

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Identifiers

PMID: 35792282
DOI: 10.1016/j.cyto.2022.155957
PMCID: PMC9250290

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