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Generation of human induced pluripotent stem cells (NIHTVBi004-A, NIHTVBi005-A, NIHTVBi006-A, NIHTVBi007-A, NIHTVBi008-A) from 5 CADASIL patients with NOTCH3 mutation.

Stem cell research - 1 May 2020

Chen Guibin, Li Zhongwen, Liu Yangtengyu, Chen Daniel, Beers Jeanette, Cudrici Cornelia, Ferrante Elisa A, Schwartzbeck Robin, Dmitrieva Natalia, Yang Dan, Zou Jizhong, Iruela-Arispe M Luisa, Boehm Manfred

Abstract excerpt

We have successfully generated induced pluripotent stem cell (iPSC) lines derived from peripheral blood mononuclear cells of five patients with Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). These cells carry the genetic NOTCH3 mutation present in their parental cells. These iPSC cells exhibited normal karyotype and phenotype, which were sustained through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32344328
DOI: 10.1016/j.scr.2020.101821
PMCID: PMC7309701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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