Serum albumin‐binding V H Hs with variable pH sensitivities enable tailored half‐life extension of biologics

Abstract excerpt

Abstract Prolonged serum half‐life is required for the efficacy of most protein therapeutics. One strategy for half‐life extension is to exploit the long circulating half‐life of serum albumin by incorporating a binding moiety that recognizes albumin. Here, we describe camelid single‐domain antibodies (V H Hs) that bind the serum albumins of multiple species with moderate to high affinity at both neutral and...

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