Article
Genome Editing As an Approach to the Study of in Vivo Transcription Reprogramming.
Doklady. Biochemistry and biophysics - 1 Jan 2020
Silaeva Y Y, Kalmykov V A, Varlamova E A, Korshunov E N, Korshunova D S, Kubekina M V, Shtil A A, Roninson I B, Deykin A V
Abstract excerpt
CDK8-mediated transcriptional reprogramming is essential for an extensive gene expression. Constitutive knockouts of the cdk8 gene are lethal at the morula stage. For modeling transcriptional reprogramming in an adult organism, we investigated the possibility to attenuate the CDK8 kinase activity with a F97G mutation in exon 3 of the cdk8 gene. According to preliminary experimental data, this mutation should lead...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.